Ok, I know promised a thread on the fascinating and important new research explaining what happened with the rare, serious side effects of AstraZeneca's and Johnson&Johnson's Covid-19 vaccines.
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All of this explains why VITT was so rare and why it could not be picked up in the trials. A lot of things had to come together. The right kind of genetic background with the right kind of antibody and at the end one particular mutation.
There may be other factors too that we don't understand yet.But with pVII identified as the problem in the adenovirus, researchers can now try to produce a version of it that is different enough that antibodies against it cannot lead to antibodies against PF4. There are a host of adenovirus vaccines in development so this is important.
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But with pVII identified as the problem in the adenovirus, researchers can now try to produce a version of it that is different enough that antibodies against it cannot lead to antibodies against PF4. There are a host of adenovirus vaccines in development so this is important.
One last point: If you have been paying attention it might be clear to you that everything I said could also happen when someone is infected with an adenovirus for a second time instead of getting a vaccine.
And yes! We know now that rarely people get these symptoms after adenovirus infection. -
One last point: If you have been paying attention it might be clear to you that everything I said could also happen when someone is infected with an adenovirus for a second time instead of getting a vaccine.
And yes! We know now that rarely people get these symptoms after adenovirus infection.I feel like a fraud because I didn't really explain the research, just the explanation that came out of it.
But it's a complicated and an important topic and I thought it's the best way to start. If you have questions, send them. I'll try to answer a few tomorrow. -
I feel like a fraud because I didn't really explain the research, just the explanation that came out of it.
But it's a complicated and an important topic and I thought it's the best way to start. If you have questions, send them. I'll try to answer a few tomorrow.@kakape As always, you did a fantastic job explaining a very complex topic. Thanks! Do I understand correctly that this might happen with any adenovirus vaccine? And is there a way to stop it from happening?
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One last point: If you have been paying attention it might be clear to you that everything I said could also happen when someone is infected with an adenovirus for a second time instead of getting a vaccine.
And yes! We know now that rarely people get these symptoms after adenovirus infection.My question exactly while reading this. Keyword is probably "rare". Thanks for summarizing all this.
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I feel like a fraud because I didn't really explain the research, just the explanation that came out of it.
But it's a complicated and an important topic and I thought it's the best way to start. If you have questions, send them. I'll try to answer a few tomorrow.@kakape No fraud detected. Thanks for the explanation. Science is amazing.
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Ok, I know promised a thread on the fascinating and important new research explaining what happened with the rare, serious side effects of AstraZeneca's and Johnson&Johnson's Covid-19 vaccines.
So, Science story by my colleague Gretchen Vogel and me is here and 🧪🧵 is coming:
https://www.science.org/content/article/rare-dangerous-side-effects-some-covid-19-vaccines-explained@kakape Clarity on complexity! Fascinating article & thread, & great to read how these insights may light the path forward.
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