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  3. Suggestions for mini PC #homelab server appreciated (~1000€).

Suggestions for mini PC #homelab server appreciated (~1000€).

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homelabbioinformaticsubuntu
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  • António DominguesK António Domingues

    Suggestions for mini PC #homelab server appreciated (~1000€). I want it for data analysis tasks (#bioinformatics) which require quite a bit of RAM, but not necessarily a GPU. I will run linux #ubuntu on it and it's not up for discussion.

    Wants:

    - loads of RAM. 32GB is a start but needs to be upgradeable to at least 64GB, and ideally 128GB
    - silent on idle because it will be next to my desk (living room)
    - energy efficient (I heard that AMZ ryzen is generally better than intel)
    - LAN port

    Si :mastodon: (he/him)S This user is from outside of this forum
    Si :mastodon: (he/him)S This user is from outside of this forum
    Si :mastodon: (he/him)
    wrote last edited by
    #7

    @keyboardpipette

    I would go for a used desktop like the Dell or HP you've linked.

    I have an older Dell as file server, and it draws 14W idle with 1 SSD and 2 HDD.

    1 Reply Last reply
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    • António DominguesK António Domingues

      Suggestions for mini PC #homelab server appreciated (~1000€). I want it for data analysis tasks (#bioinformatics) which require quite a bit of RAM, but not necessarily a GPU. I will run linux #ubuntu on it and it's not up for discussion.

      Wants:

      - loads of RAM. 32GB is a start but needs to be upgradeable to at least 64GB, and ideally 128GB
      - silent on idle because it will be next to my desk (living room)
      - energy efficient (I heard that AMZ ryzen is generally better than intel)
      - LAN port

      B This user is from outside of this forum
      B This user is from outside of this forum
      Mel
      wrote last edited by
      #8

      @keyboardpipette I don't know if the tools you are using can manage out of memory computing (https://python-bloggers.com/2025/06/handling-larger-than-memory-datasets-with-polars-lazyframe/) but if they can, my focus would be on CPU first if RAM is upgradable, so I would ditch anything below ryzen 7. Also, DDR4 won't kill your budget comapred to DDR5 but that means less powerful CPU (a ryzen AI CPU has an NPU if you want to play with LLM when Linux support is good for example). Right now I can't vouch for a model but I can add another brand GMKTek. I have one and it is nice at iddle, did not stressed it out yet

      António DominguesK 1 Reply Last reply
      0
      • António DominguesK António Domingues

        Suggestions for mini PC #homelab server appreciated (~1000€). I want it for data analysis tasks (#bioinformatics) which require quite a bit of RAM, but not necessarily a GPU. I will run linux #ubuntu on it and it's not up for discussion.

        Wants:

        - loads of RAM. 32GB is a start but needs to be upgradeable to at least 64GB, and ideally 128GB
        - silent on idle because it will be next to my desk (living room)
        - energy efficient (I heard that AMZ ryzen is generally better than intel)
        - LAN port

        Mike SpencerM This user is from outside of this forum
        Mike SpencerM This user is from outside of this forum
        Mike Spencer
        wrote last edited by
        #9

        @keyboardpipette
        Might be worth reviewing some L1Techs videos, they cover the kind of thing you might be after. Eh https://youtu.be/9Fm2m3_Sd1E

        1 Reply Last reply
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        • António DominguesK António Domingues

          Suggestions for mini PC #homelab server appreciated (~1000€). I want it for data analysis tasks (#bioinformatics) which require quite a bit of RAM, but not necessarily a GPU. I will run linux #ubuntu on it and it's not up for discussion.

          Wants:

          - loads of RAM. 32GB is a start but needs to be upgradeable to at least 64GB, and ideally 128GB
          - silent on idle because it will be next to my desk (living room)
          - energy efficient (I heard that AMZ ryzen is generally better than intel)
          - LAN port

          mkjM This user is from outside of this forum
          mkjM This user is from outside of this forum
          mkj
          wrote last edited by
          #10

          @keyboardpipette Maybe give the Teklager TLSense 10810U a look? It's primarily intended as a firewall/router appliance but looks like it might be up to what you want to do, and with 64 GB RAM and a 512 GB NVMe SSD costs about €910 plus shipping and VAT. https://teklager.se/en/products/routers/tlsense-10810U Doesn't look like it can take 128 GB RAM though; I suspect for that you'll need to move closer to the server space, which is generally incompatible with "silent" anything… 🙂

          António DominguesK 1 Reply Last reply
          0
          • António DominguesK António Domingues

            Suggestions for mini PC #homelab server appreciated (~1000€). I want it for data analysis tasks (#bioinformatics) which require quite a bit of RAM, but not necessarily a GPU. I will run linux #ubuntu on it and it's not up for discussion.

            Wants:

            - loads of RAM. 32GB is a start but needs to be upgradeable to at least 64GB, and ideally 128GB
            - silent on idle because it will be next to my desk (living room)
            - energy efficient (I heard that AMZ ryzen is generally better than intel)
            - LAN port

            Troed SångbergT This user is from outside of this forum
            Troed SångbergT This user is from outside of this forum
            Troed Sångberg
            wrote last edited by
            #11

            @keyboardpipette Might @tuxedocomputers have something suitable?

            https://www.tuxedocomputers.com/en/TUXEDO-Nano-Pro-Gen14-AMD.tuxedo

            You're buying in the wrong market conditions right now unfortunately, so costs might run away if you go for something new.

            1 Reply Last reply
            0
            • António DominguesK António Domingues

              Suggestions for mini PC #homelab server appreciated (~1000€). I want it for data analysis tasks (#bioinformatics) which require quite a bit of RAM, but not necessarily a GPU. I will run linux #ubuntu on it and it's not up for discussion.

              Wants:

              - loads of RAM. 32GB is a start but needs to be upgradeable to at least 64GB, and ideally 128GB
              - silent on idle because it will be next to my desk (living room)
              - energy efficient (I heard that AMZ ryzen is generally better than intel)
              - LAN port

              stfnS This user is from outside of this forum
              stfnS This user is from outside of this forum
              stfn
              wrote last edited by
              #12

              @keyboardpipette I would look for a high end Lenovo Tiny, M90 or similar. I have two Tinys, but with lower specs, and for me they are perfect for a silent homelab

              1 Reply Last reply
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              • mkjM mkj

                @keyboardpipette Maybe give the Teklager TLSense 10810U a look? It's primarily intended as a firewall/router appliance but looks like it might be up to what you want to do, and with 64 GB RAM and a 512 GB NVMe SSD costs about €910 plus shipping and VAT. https://teklager.se/en/products/routers/tlsense-10810U Doesn't look like it can take 128 GB RAM though; I suspect for that you'll need to move closer to the server space, which is generally incompatible with "silent" anything… 🙂

                António DominguesK This user is from outside of this forum
                António DominguesK This user is from outside of this forum
                António Domingues
                wrote last edited by
                #13

                @mkj Oh yeah, server adjacent is not what I want. I had a dell server sitting on a desk for a couple days - data needed to copied before it was wiped and shipped to another site - and it felt like I was behind a plane during lift-off 😄

                1 Reply Last reply
                0
                • B Mel

                  @keyboardpipette I don't know if the tools you are using can manage out of memory computing (https://python-bloggers.com/2025/06/handling-larger-than-memory-datasets-with-polars-lazyframe/) but if they can, my focus would be on CPU first if RAM is upgradable, so I would ditch anything below ryzen 7. Also, DDR4 won't kill your budget comapred to DDR5 but that means less powerful CPU (a ryzen AI CPU has an NPU if you want to play with LLM when Linux support is good for example). Right now I can't vouch for a model but I can add another brand GMKTek. I have one and it is nice at iddle, did not stressed it out yet

                  António DominguesK This user is from outside of this forum
                  António DominguesK This user is from outside of this forum
                  António Domingues
                  wrote last edited by
                  #14

                  @baalroga Some can do out-of-memory, and I wrote about it 🙂
                  https://amjdomingues.com/posts/2025-11-02-cmap-tile-db-build/
                  However, not all do and even if they do, some will require too much time fiddling with the code to go around the RAM limitation, time which could be used to do get results. I am not one to brute-force everything but sometimes a balance is needed.

                  TLDR; I am willing to pay a little more for convenience, even more than 1000€, because my time is precious to me and I get more fun out of the analysis.

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                  • António DominguesK This user is from outside of this forum
                    António DominguesK This user is from outside of this forum
                    António Domingues
                    wrote last edited by
                    #15

                    @visone Good points. The server will be running 24/7 but the heavy duty tasks will be in spikes, so overheating is not a concern.

                    As for the building by parts: I don't enough knowledge and, above all, time to select the parts. It's been more than 20 years since I've assembled a computer - and I had help getting the parts from IT friends 🙂

                    Assuming it doesn't go too over budget, I would rather trade money for convenience.

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                    • António DominguesK This user is from outside of this forum
                      António DominguesK This user is from outside of this forum
                      António Domingues
                      wrote last edited by
                      #16

                      @visone meaning, I don't mind getting my hands dirty and upgrading it myself with RAM/HDD but not build the whole thing. I know my limitations.

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                      • R AodeRelay shared this topic
                      • António DominguesK This user is from outside of this forum
                        António DominguesK This user is from outside of this forum
                        António Domingues
                        wrote last edited by
                        #17

                        @visone Thank you! I will add it to my list 🙂

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                        • António DominguesK António Domingues

                          Suggestions for mini PC #homelab server appreciated (~1000€). I want it for data analysis tasks (#bioinformatics) which require quite a bit of RAM, but not necessarily a GPU. I will run linux #ubuntu on it and it's not up for discussion.

                          Wants:

                          - loads of RAM. 32GB is a start but needs to be upgradeable to at least 64GB, and ideally 128GB
                          - silent on idle because it will be next to my desk (living room)
                          - energy efficient (I heard that AMZ ryzen is generally better than intel)
                          - LAN port

                          naturepokerN This user is from outside of this forum
                          naturepokerN This user is from outside of this forum
                          naturepoker
                          wrote last edited by
                          #18

                          @keyboardpipette my lab runs on cheap used small machines. I second the recommendation for small format models from workstation manufacturers, like lenovo m75q or p3. They usually have tons of aftermarket replacement parts, manuals and some are designed for long, sustained workloads.

                          Cheap used workstation/desktop replacement laptops could be a good fit too. DDR4/DDR3 ram models can support upto 128gb and are VERY cheap computes (relatively speaking).

                          António DominguesK 1 Reply Last reply
                          0
                          • António DominguesK António Domingues

                            Suggestions for mini PC #homelab server appreciated (~1000€). I want it for data analysis tasks (#bioinformatics) which require quite a bit of RAM, but not necessarily a GPU. I will run linux #ubuntu on it and it's not up for discussion.

                            Wants:

                            - loads of RAM. 32GB is a start but needs to be upgradeable to at least 64GB, and ideally 128GB
                            - silent on idle because it will be next to my desk (living room)
                            - energy efficient (I heard that AMZ ryzen is generally better than intel)
                            - LAN port

                            SMTB This user is from outside of this forum
                            SMTB This user is from outside of this forum
                            SMT
                            wrote last edited by
                            #19

                            @keyboardpipette for what it is worth i rent a server on hetzner for similar purposes since my internet connection is trash. It is about 50 USD per month, 62 GB ram, 20 threads with avx2 (sadly no avx512). But i guess for long term usage, buying one should be better

                            António DominguesK 1 Reply Last reply
                            0
                            • naturepokerN naturepoker

                              @keyboardpipette my lab runs on cheap used small machines. I second the recommendation for small format models from workstation manufacturers, like lenovo m75q or p3. They usually have tons of aftermarket replacement parts, manuals and some are designed for long, sustained workloads.

                              Cheap used workstation/desktop replacement laptops could be a good fit too. DDR4/DDR3 ram models can support upto 128gb and are VERY cheap computes (relatively speaking).

                              António DominguesK This user is from outside of this forum
                              António DominguesK This user is from outside of this forum
                              António Domingues
                              wrote last edited by
                              #20

                              @naturepoker good tip, thanks. I did a quick search for DDR4 X DDR5 RAM prices and at the moment, in this crazy market, the prices are not so different. Mind you that was a cursory search.

                              But, I'll continue researching.

                              naturepokerN 1 Reply Last reply
                              0
                              • SMTB SMT

                                @keyboardpipette for what it is worth i rent a server on hetzner for similar purposes since my internet connection is trash. It is about 50 USD per month, 62 GB ram, 20 threads with avx2 (sadly no avx512). But i guess for long term usage, buying one should be better

                                António DominguesK This user is from outside of this forum
                                António DominguesK This user is from outside of this forum
                                António Domingues
                                wrote last edited by
                                #21

                                @bioinfhotep I did look at cloud solutions, including Hetzner, but as you said, it's not a long term solution. The thing is that I only have a couple of hours, or less, per day for my pet projects, so I want something that is available and fuss free from the get go. Cloud is nice but expensive for such convenience, or cumbersome if one wants to have it on the cheap - I would have to pay for storage or transfer the data on the go, Etc.

                                But the price point is getting there.

                                SMTB 1 Reply Last reply
                                0
                                • António DominguesK António Domingues

                                  @naturepoker good tip, thanks. I did a quick search for DDR4 X DDR5 RAM prices and at the moment, in this crazy market, the prices are not so different. Mind you that was a cursory search.

                                  But, I'll continue researching.

                                  naturepokerN This user is from outside of this forum
                                  naturepokerN This user is from outside of this forum
                                  naturepoker
                                  wrote last edited by
                                  #22

                                  @keyboardpipette oh price differential is for used machines already kitted out with amount of ram you're looking for. If you're buying ddr4 sticks directly there won't be too much difference.

                                  1 Reply Last reply
                                  0
                                  • António DominguesK António Domingues

                                    @bioinfhotep I did look at cloud solutions, including Hetzner, but as you said, it's not a long term solution. The thing is that I only have a couple of hours, or less, per day for my pet projects, so I want something that is available and fuss free from the get go. Cloud is nice but expensive for such convenience, or cumbersome if one wants to have it on the cheap - I would have to pay for storage or transfer the data on the go, Etc.

                                    But the price point is getting there.

                                    SMTB This user is from outside of this forum
                                    SMTB This user is from outside of this forum
                                    SMT
                                    wrote last edited by
                                    #23

                                    @keyboardpipette for convenience i think it is quite convenient on hetzner since i use vs-code remote-ssh anyway all the time and mount remote folders when needed using sshfs. It is a bit expensive (there is a one time setup fee) even though transfer bandwidth is quite large but ssd pricing is an issue

                                    1 Reply Last reply
                                    0
                                    • António DominguesK António Domingues

                                      Suggestions for mini PC #homelab server appreciated (~1000€). I want it for data analysis tasks (#bioinformatics) which require quite a bit of RAM, but not necessarily a GPU. I will run linux #ubuntu on it and it's not up for discussion.

                                      Wants:

                                      - loads of RAM. 32GB is a start but needs to be upgradeable to at least 64GB, and ideally 128GB
                                      - silent on idle because it will be next to my desk (living room)
                                      - energy efficient (I heard that AMZ ryzen is generally better than intel)
                                      - LAN port

                                      Rupert OverallR This user is from outside of this forum
                                      Rupert OverallR This user is from outside of this forum
                                      Rupert Overall
                                      wrote last edited by
                                      #24

                                      @keyboardpipette Just a note: if you want to run this as a headless server, then it doesn't necessarily need to be on your desk. That might open up some less-quiet options.
                                      Also, if it is only in use for short periods and can be shut down the rest of the time, then low-power mode is also no longer important and even more options open up.

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