later also to morphine,[5][6] which were not illegal during his time.
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later also to morphine,[5][6] which were not illegal during his time. As revealed by Osler's diary, Halsted developed a high level of drug tolerance for morphine. He was "never able to reduce the amount to less than three grains daily" (approximately 200 mg).[7] Halsted's addictions resulted from experiments on the use of cocaine as an anesthetic agent that he performed on himself.[8]
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