@rayckeith @rdnielsen Yeah, it was like finding out there’s a combination of acetaminophen and ibuprofen that triggers an opioid like response in your brain, re serotonin release in descending pathways. A fixed combination, typically 1000 mg of acetaminophen and 400 mg of ibuprofen, is the formula suggested as a non-opioid alternative.https://pubmed.ncbi.nlm.nih.gov/39068515/Is it as efficacious as small dose opioids? anecdotally I’d say it’s close, but I worry about long term use re liver.